STANOLAB (Winstrol)

Anabolic hormone that promotes the process of rebuilding body tissues and reverses body catabolism. It is used therapeutically to treat hereditary angioedema, cryofibrinogenemia, a decrease in the severity and frequency of seizures, and an increase in muscle mass in athletes.

Mechanism of action and pharmacokinetics

Stanozolol is a synthetic steroid derived from testosterone that enhances muscle development. However, it also has the androgenic properties of male sex hormones (testosterone). As with all other anabolic steroids, Stanozolol suppresses pituitary gonadotropic function and can have a direct effect on the testes. Stanozolol increases plasma levels of LDL and reduces HDL levels, eventhough total cholesterol or triglycerides are not modified. When the administration ends, these levels return to normal. Elimination is through the kidneys, a small part is eliminated through the feces, due to enterohepatic incubation.

Treatment of hereditary angioedema: oral administration

- Adults: Initially, 2 mg orally three times a day. Once the angioedema seizures have subsided, the doses can be reduced at intervals of 1 to 3 months until reaching the maintenance dose of 2 mg once every other day.

- Children: The safety and efficacy of stanozolol in children with hereditary angioedema have not been determined. A benefit / risk assessment of the use of Stanozolol should be done in children and skeletal maturation monitored. Long-term treatment is not recommended (risks increase with chronic use).

Treatment of cryofibrinogenemia: Oral administration

- Adults: Doses of 2 mg twice a day have been used for 5 months. The lesions begin to disappear after two weeks to a month of treatment.

Increase in muscle mass in athletes:

The doses used in some clinical studies to scientifically determine the increase in muscle mass and strength have ranged from 6 to 8 mg / day for no more than 2 or 3 weeks periods. However, once the drug is stopped, its effects wear off in 6 to 10 weeks. With the use of this drug, adequate calorie and protein support is important to maintain a positive nitrogen balance.

STANOZOLOL DEPOT intramuscular injection.

- Adults: 1 ml every 2 - 3 weeks

- Children: up to 2 years: 0.5 ml, every 2 - 3 weeks.

From 2 - 6 years: 0.5 to 1 ml, every 2-3 weeks, according to the doctor's criteria.

STANOZOLOL DEPOT is an aqueous suspension specially studied for long-term absorption free of local irritating effects. Its use is preferred as long as the physician considers suitable parenteral administrations spaced apart in time. It is important to complement the treatment with a rich and balanced diet.

Contraindications

The use of stanozolol is contraindicated in male patients with breast carcinoma or with suspected or latent carcinoma of the prostate. In women, stanozolol is contraindicated in hypercalcemic breast cancer. Androgenic steroids can stimulate osteolytic bone resorption.

Anabolic steroids, including stanozolol, belong to category X of risk during pregnancy. Animal studies have shown that these drugs cause fetal masculinization. The potential risk of thesis drugs is clearly greater than the theoretical therapeutic benefit. Therefore, the use of this drug in pregnant women is contradindicated. It is not known whether Stanozolol is excreted in significant amounts in human milk. Due to the possibility of serious adverse reactions in the nursing infant, it is recommended to stop breastfeeding or avoid the administration of this drug.

Hepatic peliosis, a disease in which liver tissue and sometimes the spleen are replaced by cysts filled with blood has occasionally been observed in subjects treated with anabolic androgens. These cysts usually present with minimal liver dysfunction. But in other cases they can be associated with liver failure. Also, these cysts are not apparent until severe liver failure occurs or abdominal bleeding takes place. Usually, drug withdrawal results in the complete disappearance of the lesions.

Liver cell tumors have also been reported, most of them benign and androgen-dependent, eventhough there may be some malignant tumors. The interruption of the treatment usually causes the tumors to regress and their progression stops. However, tumors associated with androgens or anabolic steroids are highly vascularized and can be asymptomatic until an intra-abdominal bleeding occurs which can be fatal.

Anabolic steroids cause lipid abnormalities that increase the risk of atherosclerosis. These changes consist of an increase in LDL and a decrease in HDL that can reach significant levels with a corresponding increase in the risk of coronary heart disease. Like all other steroids, Stanozolol is contraindicated in diabetes mellitus, in the nephrotic phase of nephritis, and in the presence of seizure disorders.

Anabolic steroids should be used with caution in children and adolescents, as it can cause premature closure of the epiphysis, early sexual development in men, and masculinization in the female sex. Epiphysis maturation may be faster as growth continues and 6 months after discontinuation of medication.

Cautions and Warnings:

Anabolic steroids should be used with caution in children and adolescents, as it can cause premature closure of the epiphysis, early sexual development in men, and masculinization in the female sex. Epiphysis maturation may be faster as growth continues and 6 months after discontinuation of medication.

Interactions with other medications

Effects of heparin and oral anticoagulants can be increased by androgens, including stanozolol.

Antidiabetic drugs (insulin): there are studies in which a potentiation of the hypoglycemic effect has been shown, with a risk of toxicity. The mechanism has not been established, but it has been suggested that with increasing metabolic activity of anabolics and increasing glucose consumption, the effect of hypoglycemia may be increased.

Do not use in case of hypersensitivity to any of the components, pregnancy or lactation.

The adverse effects of Stanozolol are, in general, frequent, moderately important and irreversible in some cases. During therapy stanozolol adverse reactions in the liver have been described (hepatic peliosis and liver tumors) and cholestatic jaundice. In most cases, these effects go away when treatment is stopped. There have also been reported cases of diarrhea, nausea / vomiting, restlessness, insomnia, virilization, hirsutism, clitoral hypertrophy, acne, inhibition of testicular function with oligospermia and sodium, potassium, chloride, and water retention.

When Stanozolol is used by athletes and gymnasts, adverse reactions have been described in up to 40% of men and 50% of women. The most common side effects experienced by men are increased sexual urges, acne, hirsutism, irritability, fluid retention, hypertension, insomnia, depression, increased appetite, hair loss, and gynecomastia. In women, the most frequently observed adverse reactions are virilization, acne, and fluid retention.

The use of stanozolol in adolescents interferes with growth in height.

When used in super therapeutic doses there is a decrease in the quantity and quality of sperm in men, which produces, within a few months, sterility. The exact time needed to return to normal is not known, although some authors estimate 5 to 6 months after the drug is withdrawn. Long-term administration of stanozolol produces hypogonadism with testicular atrophy and azoospermia.

Overdose (signs, symptoms and treatment of behavior):

No acute toxicity has been reported for indicated therapeutic doses. In case of an overdose go to the Emergency Medical Center.

Box with 80 tablets x 10 mg

Box with 1 VIAL x 20 ml x 100mg

Store at a temperature below 25 ° C in a dry place.

Keep out of the reach of children.

sale only with prescription.